Parkinsons Disease Essays - Neuroscience, Biology, Brain

Parkinson's Disease : Parkinson's disease affects the nerve cells in the brain that produce dopamine. Parkinson's disease symptoms include muscle rigidity ,tremors , and changes in speech and gait. After diagnosis, treatments can help relieve symptoms. Figure SEQ Figure \* ARABIC 3 :Dopamine levels in normal and a pakinson's affected neuron Stem cell therapy in parkinson's disease : Doctors firstly isolated adult stem cells from the patient's brain, they were then cultured in vitro and encouraged to turn into dopamine-producing neurons. As soon as tests showed that the cells were producing dopamine they were then re-injected into the man's brain. After the transplant, the man's condition was seen to improve and he experienced a reduction in the trembling and muscle rigidity associated with the disease. Brain scans taken 3-months after the transplant revealed that dopamine production had increased by 58%, however it later dropped but the Parkinson's symptoms did not return. The study is the first human study to show that stem cell transplants can help to treat Parkinson's. The use of fetal-derived neural stem cells has shown significant promise in rodent models of Parkinson's disease, and the potential for tumorigenicity appears to be minimal. The authors report that undifferentiated human neural stem cells ( hNSCs ) transplanted into severely Parkinsonian 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated primates could survive, migrate, and induce behavioral recovery of Parkinsonian symptoms, which were directly related to reduced dopamine levels in the nigrostriatal system ( 5 ) . Working with these cells, the researchers created dopamine neurons deficient in DJ-1, a gene mutated in an inherited form of Parkinson's. They report that DJ-1-deficient cells -- and especially DJ-1-deficient dopamine neurons -- display heightened sensitivity to oxidative stress, caused by products of oxygen metabolism that react with and damage cellular components like proteins and DNA. In a second paper, they link DJ-1 dysfunct ion to the aggregation of alpha- synuclein , a hallmark of Parkinson's neuropathology. ( 6 , HYPERLINK "http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3068820/" \l "b7-ijhs-3-2-0227" 7 ) In summary most of studies using aborted human embryonic tissue indicate that: Clinical benefit does occur; however, the benefit is not marked and there is a delay of many months before the clinical change. Postmortem examinations show that tissue grafts do survive and innervate the striatum. PET scans show that there is an increase in dopamine uptake after transplantation. Follow up studies show that long term benefit does occur with transplantation . ( 8 )

Free Essays on The Japanese Quince

Symbolic Sapling Literature is a wonderful form of escape from our daily stresses, but not every book on the shelf should be taken at face value. In John Galsworthy’s â€Å"The Japanese Quince,† a small ornamental Oriental tree in the heart of a nearby public park plays a powerful role and is an important symbol in the life of the â€Å"well known† Mr. Nilson. The quince tree represents life, growth, freedom and joy, all of which Mr. Nilson is lacking in his daily schedule. Mr. Nilson is a well-to-do London businessman who follows the patterns of the wealthy and takes advantage of its benefits, yet Mr. Nilson is far more unfortunate than the classification he looks down upon. Mr. Nilson may have the life of the wealthy, but he does not live a rich life. An average day in the life of Mr. Nilson consists mainly of schedule and order, to everything its own place and time. As mentioned before, his breakfast is served to him at precisely eight-thirty each morning. On one specific morning, Mr. Nilson feels an uncomfortable sensation â€Å"just under his fifth rib† (73), and proceeds to exit out his French window in his black frock coat and descend the â€Å"scrolled iron steps into the fresh air† (73). As he reaches the bottom of the staircase and enters the public garden, he notes that his â€Å"feeling of emptiness† (73), as he describes it, essentially has not diminished but in fact had increased in the morning air. As he enters into the garden, a little bl! ackbird lures him toward a glistening, lively, pretty, yet unfamiliar tree whose â€Å"leaves the sunlight glistened† (74), located in the heart of the park. He studies the tree and its features as its warmth and happiness seem to draw him closer and entrance him further in the tree, making the queer feeling in his chest fade away unnoticed. Mr. Nilson slowly withdraws his fascination from the sapling only to be startled by the presence of his neighbor, Mr. Tandram, who is a... Free Essays on The Japanese Quince Free Essays on The Japanese Quince Symbolic Sapling Literature is a wonderful form of escape from our daily stresses, but not every book on the shelf should be taken at face value. In John Galsworthy’s â€Å"The Japanese Quince,† a small ornamental Oriental tree in the heart of a nearby public park plays a powerful role and is an important symbol in the life of the â€Å"well known† Mr. Nilson. The quince tree represents life, growth, freedom and joy, all of which Mr. Nilson is lacking in his daily schedule. Mr. Nilson is a well-to-do London businessman who follows the patterns of the wealthy and takes advantage of its benefits, yet Mr. Nilson is far more unfortunate than the classification he looks down upon. Mr. Nilson may have the life of the wealthy, but he does not live a rich life. An average day in the life of Mr. Nilson consists mainly of schedule and order, to everything its own place and time. As mentioned before, his breakfast is served to him at precisely eight-thirty each morning. On one specific morning, Mr. Nilson feels an uncomfortable sensation â€Å"just under his fifth rib† (73), and proceeds to exit out his French window in his black frock coat and descend the â€Å"scrolled iron steps into the fresh air† (73). As he reaches the bottom of the staircase and enters the public garden, he notes that his â€Å"feeling of emptiness† (73), as he describes it, essentially has not diminished but in fact had increased in the morning air. As he enters into the garden, a little bl! ackbird lures him toward a glistening, lively, pretty, yet unfamiliar tree whose â€Å"leaves the sunlight glistened† (74), located in the heart of the park. He studies the tree and its features as its warmth and happiness seem to draw him closer and entrance him further in the tree, making the queer feeling in his chest fade away unnoticed. Mr. Nilson slowly withdraws his fascination from the sapling only to be startled by the presence of his neighbor, Mr. Tandram, who is a...

Writing a Case Analysis

Writing a Case Analysis Writing a Case Analysis Writing a Case Analysis: How to Cope with Case Analysis To write a good writing a case analysis, you have to be good in case analysis matters. In order to study the notion of case analysis you have to spend some definite amount of time, as this activity demands much of your attention and hard working. While you are going to read this article, it is essential to make notes in order you not to miss a single idea while reading. Success Depends on Depth of Case Study Analysis To make a successful case analysis and to manage to cope with writing a case analysis essay, you have to analyze the history of the company or business you are going to deal with in your essay and its growth in a projection of time passing. You see the past of any business is an aspect, which greatly influences the present situation of running business and the future one. That is why you have to make a thorough analysis in your writing a case analysis of the history of foundation and running the business in the past in order to evaluate the state and position of the business at the present time and in order to be able to make any business forecasts for future. Structure of the company is another point to be analyzed in your writing a case analysis, as structure is one of the key elements, which predetermines either success or failure of the company under consideration: Focus on Strong and Weak Points The following step you should make in writing a case analysis is to analyze all strong and weak points of the company under discussion, its strengths and weaknesses if speaking with the other words. External Environment Analysis Is Equally Important Analyzing external environment is that point without which it is impossible to cope with writing a case analysis in a successful way. Threats and opportunities of the market are those elements to be paid a special attention to. At this point, you have to determine the level of the ability of the company to be competitive at the market, its bargaining powers, and the existing threat of copies of the products, or if speaking with scientific language the level of threat of appearance of substitute products. Our Writers Are Ready To Help With Writing A Case Analysis These are the main steps you have to walk while writing a case analysis essay. Hope, with the help of our article you are going to write a successful work. By the way, writing a casual analysis paper is another one assignment, which is often used by the professors. If you have received a task of writing a casual analysis paper, you are welcome to visit our site and find all the necessary information you may need to write a case analysis paper. Popular posts: Science Research Paper Research Papers Proposal Research Paper Topic Ideas Research Paper no Plagiarism Research Paper Help

Microeconomics Principles Essay Example | Topics and Well Written Essays - 750 words

Microeconomics Principles - Essay Example Moreover, this paper will present real events in order to present the ideas in a way that is easy to understand. Gains from trade In a decision to get a haircut, Gains from trade can be understood through determination of the decision made by a consumer depending on the other services available. Therefore, a decision to have a haircut can result to consumers having their lives than they would if there was no trade. In this case, there is need to explore the simple example concerning a situation involving two service that are traded (Broadstock, 3). For instance, considering a situation where there are two service providers such as a barber and a tailor that are located in different location. Gain from trade can be effectively illustrated in a situation when each service provider can only offer one service only. In this case, the barber can only offer haircutting services, while the tailor can only offer dressmaking services. The gains from trade occur in a situation where the barber realizes that he or she needs some clothes and that would call for services from the tailor (Eicher, Mutti and Turnovsky, 1). On the other hand, the tailor can realize he needs a haircut and this would call for services from a barber. In fact, this is in a situation where the barber and tailor are able to gain from trading with each other (Broadstock, 4). On the other hand, there are situation where each of these service providers can offer both services; in this case, the tailor and barber have the skills to of hair cutting and dressmaking. Approaching this matter with another perspective, these service providers can collaborate and work together, thereby consuming similar amount of services without occurrence of trade. Opportunity cost This can be discussed in reflecting on same example used in the previous discussion. In this case, the barber and tailor had absolute advantage in the process of offering haircutting and dressmaking services to customers. However, the absolute advan tage forms a basis of understanding the opportunity cost, whereby this can assist in determining occurrence of the trade. Therefore, opportunity cost is regarded as the cost of forgoing a particular service or good in order to obtain something else (Broadstock, 6). For instance, the when a barber has the ability to offer dressmaking services, he can decide to forgo this making his own dress at a lower opportunity cost he can decide to seek services from a tailor. In fact, the concept of opportunity cost is significant in determination of the amount of benefits derived from trade existing between two service providers. In this case, this is an indication that situation where two service providers are facing similar opportunity cost, there are increased chances of gains from trade occurring. Opportunity costs increases in situations where the services or goods involved increases in terms of production (Merrewijk, 30). This is presented through a PPF (production possibility frontier), where an increase in the opportunity cost leads to bowing out of the PPF, thereby forming a circle shape. In situation where the opportunity cost are constant despite the services or goods produced, the PPF remains constant, thereby taking a straight line that is triangular. Decreasing opportunity cost is presented in a PPF by a subsequent decrease in the production of goods or services; in fact, this is depicted as PPF takes a bowed shape that resembles a crescent moon (Merrewijk, 30). Price elasticity of demand Understanding of price elasticity of demand can assist in evaluating the responsiveness of demand in terms of changes in prices for a given commodity, however, it is indispensable to recognize that in situation where

Endocrine Disruptors Essay Example | Topics and Well Written Essays - 1000 words

Endocrine Disruptors - Essay Example These chemicals have been found to act as estrogens, anti-estrogens, androgens, anti-androgens, or to interfere with thyroid hormone, cortisol, insulin, or growth regulators. Moreover, since animals and human foetal development is primarily dependent on hormonal levels at various phases of development, the effects of these endocrine disrupting chemicals on the endocrine, reproductive, neurological, and immune systems have been found to be very serious, if not catastrophic (Windham, 2000). TCDD dioxin is the most toxic of a class of organochlorine chemicals including chlorinated dibenzo-p-dioxins (CDDs), dibinzofurans (CDFs), polychlorinated biphenals (PCBs), brominated dibenzo-p-dioxins (BDDs), brominated dibenzofurans (BDFs), and polychlorinated pesticides etc. These groups of chemicals have been shown to exert hormonal effects that disrupt the endocrine system of wildlife resulting in adverse effects on reproductive system development and hormones, foetal development, and the immune system at extremely low levels of exposure (Windham, 2000; Are Environmental Hormones Emasculating Wildlife, 1994). Dioxins have been found to have both estrogenic and anti-estrogenic effects depending on the organ or tissue affected. The toxic metals mercury, lead, and cadmium as well as phenols have also been found to have reproductive and endocrine system disrupting effects (Windham, 2000). Chemicals with estrogenic effects cause cells to produce surplus levels of oestrogen, which has been linked to breast cancer, testicular cancer, lowered sperm counts, and malformation/mutations of male sex organs, and a decreased number of successful male births. Exposure to relatively low levels of these chemicals have been documented to have had catastrophic effects on populations of Beluga whales, alligators, turtles, mink, otters, bald eagles, osprey, cormorants, terns, herring gulls, migratory birds, chickens, lake trout, chinook and coho salmon, etc. For example only 60 parts per billion (ppb) of DDE are required to cause anti-androgenic effects on male test animals (Colborn, 1999; Pritchard, 2004). These chemicals act in a variety of ways; however, their mechanism of action could be broadly described as mimicking oestrogen thereby increasing oestrogen levels in the blood, anti-estrogenic; binding with oestrogen receptors or anti-androgenic; binding with androgen receptors. Some chemicals known to bind to estrogens receptors include insecticides (dichlorodiphenyl-trichloroethane (o,p'-DDT), methoxychlor, and chlordecone); a monomer used in plastic (bisphenol A); an alkylphenol surfactant used in detergents, cosmetics and toiletries, and other household products (octylphenol); and a plasticizer (butyl benzyl phthalate (BBP). Other compounds known to bind to androgen receptors include the fungicide vinclozolin and 1,1dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p'-DDE) the persistent in vivo metabolite of DDT. Polychlorinated biphenyls (PCBs) and 2,3,7.8-tetrachlorodibenzo-p-dioxin (TCDD) could all disrupt reproduction and development via several mechanisms (CLS, 1999; Developmenta l Effects, 1993). Laboratory studies investigating the endocrine disrupting capacity of these chemicals

Ethics and Issues in Counseling Essay Example for Free

Ethics and Issues in Counseling Essay Question 1 a) Ethics are a list of conduct or principles drawn with the purpose of providing a guideline to what defines professional practice (Corey, 2009) while values are the basis of one’s thoughts or ideals in which decisions are generated (Manthei, 1997). Certain institutions derive their own core values to help provide a guide to â€Å"proper† behaviors. In simple terms, ethics are like â€Å"rules† within a society, culture or institution while values are like â€Å"policeman† in our mind, helping us determine between desirable and non-desirable behaviors while keeping in mind these â€Å"rules† that governs them (Dolgoff, Loewenberg Harrington, 2008). The professional code of ethics is a guide designed to determine what constitutes professionalism in which governs the institution in the best interest of the values of the profession (Corey, 2009). It not only serves as a clarification to existing and future members of the institution or association governing it, but also helps supports the mission and vision of the institution or association. Its objective is to provide guidelines to practitioners, clarify the professional stand of institutions and organizations governing these practitioners, and at the same time protecting the rights of clients (consumers) (Corey, Corey Callanan, 2003). The Professional Code of Ethics also helps to bound practitioners ethically so that they do not try to impose their own values onto others and behave as moral authorities. While the Professional Code of Ethics may be written as clear as possible and as comprehensive as possible, in reality there are person’s feelings, values, as well as emotions involved, which are absent during the compilation (Betan, 1997). The ACA Code of Ethics (2005) states â€Å"Counselors terminate a counseling relationship when it becomes reasonably apparent that the client no longer needs assistance, is not likely to benefit, or is being harmed by continued counseling.† The practitioner would be caught in a conflict when his agency deems the client fit to be discharged but he feels otherwise (Betan, 1997). Ethical guides may not be easily integrated into one of vast cultural diversity like that of Singapore as most of the Professional Code of Ethics were formulated within that of a Western context. As such, cultural, socioeconomic as well as linguistic differences may have been neglected in the process (Betan, 1997); while the code may hold autonomy of client at high regards, the cultural stand of the client may not be so. Confidentiality itself also poses a great arguing standpoint especially in a multicultural context whereby there are traditions as well as cultural rules to adhere to (Welfel, 2012). Another important point to not neglect while considering the limitations of the Professional Code of Ethics is its congruency towards the local state laws (Betan, 1997). For instance, one state regulation for consumption of alcohol may differ that from another. In putting ethics into consideration, practitioners should also be aware of their own local state laws. b) Two values that I value as important in life are honesty and being just, ie to try my best to make sure I give or receive equal treatments. Being a straightforward person, I believe in being honest at all times and to take responsibility for your own actions. I believe in giving others a benefit of doubt, unless I have concrete evidence that he/she is telling a lie. I uphold the value of equality; to treat others the way you would like to be treated. Thus, I try my very best not to be bias and constantly remind myself to stay in a neutral stand when others are involved. Because I believe strongly in always giving others the benefit of doubt, I would not doubt on the credibility of my clients’ words even though they might sound absurd. By doing so, it gains trust from clients and help in rapport building with clients. On the flip side, if the client is not a willing client, he might manipulate the trust I have and may try to lie and mislead me. Due to my eagerness to be non-bias and be fair and just as much as I can, I may end up trying to argue and inevitably try to prove myself when some clients at times show biasness towards me due to my experience and age. This  could hinder my work with them as I might try to convince them that they are being bias and indirectly in one way or another, try to argue or indirectly try hard to prove myself. This may come across to some as being argumentative, especially when I always have something to retort back whenever they say something negative, thus spoiling the therapeutic relationship. Of course, being non-bias is important in the counseling relationship as it helps one to not be judgmental and to always maintain a partial perspective. Question 2 The 6 moral principles forming the basis of functioning at the highest level of ethical profession as summarized by Corey et al. (2003, p.16) are autonomy, veracity, justice, nonmaleficence, beneficence, and fidelity. Autonomy refers to the rights or freedom to decide and make independent decisions or choices in one’s own accord within a social and cultural context. Thus, the respect for such autonomy brings about an acceptance that others have a right to choose and act in accordance to his own wishes, unless they hinder the rights of others (Altmaier Hansen, 2011); practitioners aim at encouraging independence in client and discourage client’s dependency on him. Veracity or truthfulness refers to the practitioner being obliged to be truthful with his clients (Corey et al., 2003). The guideline in the Ethical Principles of Psychologists and Code of Conduct of the American Psychological Association (2002) states, â€Å"Psychologists do not make false, deceptive, or fraudulent statements†¦Ã¢â‚¬  (para. 5.01b) since trust is very important in building up a good therapeutic relationship with clients. Justice means to be fair by providing equal treatment to all regardless of culture, religion, race, gender, socioeconomic status, sexual orientation, disability or age, as they are entitled to equal access and treatment (Corey et al, 2003). To be nonmaleficence means to not cause harm, including actions that might pose a risk to harm another (Altmaier Hansen, 2011). Practitioners are responsible for their clients to ensure that their risks for exploitation or might result in potential harm are brought down to a minimal (Corey et al, 2003). Beneficence refers to promoting the good and the wellbeing of clients and of others, to help clients grow and develop in their cultural context as well as doing good in their social context (Corey et al, 2003). In short, practitioners are responsible towards contributing to the welfare and growth of another being (Altmaier Hansen, 2011). Lastly but not least, fidelity means to be truthful in making honest and realistic commitments and honoring these commitments (Corey et al, 2003). It is very important to build a trusting relationship between the practitioners and the people whom they work with and thus practitioners are responsible to make sure they honor fidelity at least on their end (Altmairt Hansen, 2011). Question 3 a) The 8 essential personal attributes of an effective counselor are emotional intelligence (EQ), warmth and care, unconditional positive attitude (regard), genuineness and authenticity, patience, analytical ability, person-centered and nurturing style of communication and lastly, clear and specific communication. Emotional intelligence is defined as the ability to be able to distinguish and have self-awareness of one’s own as well as others’ emotions and feelings, and to be able to use this and guide one’s behavior and thinking, hence encourages development of emotional closeness with the client (Coetzee Jacobs, 2006). Warmth and care is important in the therapeutic relationship in rapport building as it helps show client that the practitioner is genuinely concern (Coetzee Jacobs, 2006). When warmth and care is present, practitioner is more aware of client’s cognitive and  emotional needs and the relationship will be more accepting towards each other (Coetzee Jacobs, 2006). Unconditional positive attitude (regard) is important because it challenges client’s beliefs that if they do not behave in a certain way, others would not accept them. Client had to be sure that his counselor would still see him in the same way after the ‘awful truth’ is made known (Dryden, 1999). The role of genuineness simply means to be yourself; to be sincere, transparent and not putting on a false front (Palmer Milner, 2006). This role of being genuine and authentic is one that is most challenging, as it requires one to have very high level of self-awareness (Palmer Milner, 2006). It is important for counselors to have this quality due to the high level of trust needed in order to build effective therapeutic relationship with clients. Patience is an important attribute as different types of clients requires different amount of time to build the trust with practitioners and to be able to open up. While some clients do not have difficulty expressing themselves, some of them do find great difficulty in doing so and would then require much more patience and time from the counselor. Analytical ability is important in listening as it helps the counselor to be able to analyze his own emotions as well as facial expressions while listening to the client (Singh, 2007). In terms of case study, analytical ability is also important to the counselor in helping him to analyze and decipher the bulk of information being presented to him (Singh, 2007). Person-centeredness style of communication refers to the ability to communicate to accept another as a complete unique individual (Wood, 2009). That is to say, counselors do not form pre-conceptualized ideas on how the person is like and not make assumptions during the conversation with client. Nurturing communication occurs when parties involved in the conversation relate to each other in a caretaking manner; indicating to each other that the relationship is being valued (Wood, 2009). Last but not least, clear and specific communication is very important in ensuring that the counseling session is being communicated in the way that it is meant to, without allowing either parties involved to have any misunderstandings after the session. b) If I were to choose 3 attributes that I think are important for myself to undergo the necessary personal transformation, it would be patience, analytical ability and unconditional positive regard. I think that I sometimes lack patience in a counseling session and tend to unknowingly try to rush the conversation by interrupting and not giving client enough time to think about what was being said or asked. Also at times, client may need time for reflection, resulting in pauses during the conversation. While I understand the importance of having such ‘quiet moments’ in a counseling session, I tend to be impatient and would unknowingly try to say something to fill up these ‘uneasy moments of silence’. Analytical ability is something, which I feel I am lacked of. I find myself ‘lost’ in long lengthy conversations at times and unable to ‘process’ huge amounts of information shared. I tend to be more straight-forth in my facial expressions too, and I hope to be more cautious in this area, thus being able to give information being shared more thoughts instead of just deciphering it from the surface level. To be able to achieve complete unconditional positive regard in a conversation is I feel, requires that of a high cognitive level. As every single individual comes from a different background and different culture and social environment, unconditional positive regards is important if counselors want to build on having a therapeutic relationship with client. Without it, clients would not want to return for further therapies or might refrain from sharing certain important information, which could be helpful in the therapeutic process. References: American Psychological Association. (2002). Ethical principles of psychologists and code of conduct. Washington, DC: Author. Altmaier, E.M. Hansen, J.C. (2011). The Oxford Handbook of Counseling Psychology. NY: Oxford University Press Betan, E.J.(1997). Toward a hermeneutic model of ethical decision making in clinical practice. Ethics Behaviour, 7(4), 347-365. doi: 10.1207/s15327019eb0704_6 Coetzee, M. Jacobs, H.R. (2006) Career Counselling and Guidance in the Workplace. Cape Town, South Africa: Juta and Company Corey, G. (2009). Theory and Practice of Counseling and Psychotherapy (8th Ed, pp. 37) CA: Cengage Learning Corey, G., Corey, M.S. Callanan, P. (2003). Issues and Ethics in the Helping Professions. (6Th Ed) CA: Brooks/Cole Dryden, W. (1999) Four Approaches to Counselling and Psychotherapy. NY: Routledge Dolgoff, R., Loewenberg, F.M. Harrington, D. (2008). Ethical Decisions for Social Work Practice (8Th Ed, pp. 19-23) CA: Cengage Learning Manthei, R. (1997). Counselling: The Skills of Finding Solutions to Problems. NZ: Routledge Palmer, S. Milner, P. (2006) Integrative Stress Counselling: A Humanistic Problem-Focused Approach. GB: Sage Publications Co. Singh, K. (2007). Counselling Skills for Managers. New Delhi: PHI Learning Pvt. Ltd. Wood, J.T. (2009) Interpersonal Communication: Everyday Encounters. CA: Cengage Learning Welfel, E.R. (2012). Ethics in Counseling Psychotherapy (5th Ed, pp. 150-160) CA: Cengage Learning.

Trepanation, Spirituality and Loneliness :: Biology Essays Research Papers

The search for a "higher level of consciousness" is one that seems to be as old as consciousness itself. Practices such as the ritualistic or religious consumption of peyote, ayahuasca, psilocybe mushrooms or other such naturally-occuring hallucinogenic drugs, self-deprivation and transcendental meditation are just a few of the countless ways in which mankind has sought to expand the limits of human experience; these practices are still a mainstay in many modern countercultures. They are also very well-known and documented practices. There exists, however, a radical surgical procedure, as old as the aforementioned practices but far less notorious in the general public, which purports to result in the same sort of enlightenment: trepanation, also known as trephination. (Be prepared: likely, the primary reason that trepanation has not received so much attention from popular culture is that it is far more extreme than the other methods mentioned above.) What is trepanation? Strictly speaking, it is the practice of drilling, scraping or in any other way creating a small hole in the skull down to, but not through, the dura mater, or the thick, tough membrane that contains the brain. Archeological evidence tells us that it was performed by ancient cultures on every continent; the oldest trepanned skulls that have currently been found date as far back as 3000 B.C (approximately). In almost all cases, the evidence points to the trepanation having been performed with skill and a great deal of precision - it was clearly a procedure that had ritualistic import. (1) What purpose could this operation possibly serve? In early documented incarnations, trepanation existed as a cure for mental illness - it was believed that mental illnesses were the result of demons living within the skull, and thus a hole was made in the skull through which these demons could escape. The more modern perspective on trepanation as a means of expanding consciousness was started in by Bart Hughes when his text "The Mechanism of Brainbloodvolume ('BBV')" was published in 1962. (1) Bart Hughes' theory can be summed up as follows: "...as we mature and age our skulls harden, restricting blood flow to the capillaries of the brain....children, especially babies with their "soft spot", had a clearer outlook on the world because their brains were free to receive more cerebral blood volume than...our adult brains with hermetically-sealed skulls." (1) There are many ways to increase brainbloodvolume (the self-explanatory term coined by Hughes, hereafter referred to as BBV) tempor arily, such as standing on one's head, quickly moving from a hot to a cold bath, or the consumption of psychedelic drugs; however, according to Hughes trepanation is the only way to increase BBV permanently.

Dramatic devices and events used by Miller Essay

‘You’re the Devil’s man! ‘ When Mary finally buckles under the weight of Abigail’s power over her and her intelligent reaction to the situation- the accusation against Mary of witching her, she blames Proctor of witchcraft, thus condemning the whole of Salem to madness, and taking away the lives of Proctor and many other innocents. This event marks the end of any possibility of sanity in Salem, and is ruinous for the once peaceful town. The other accusation in this act is the blame placed on Abigail by Proctor that Abigail is a whore. Even though it would seem the most far-fetched and outrageous claim made in this act, it is the only truthful one. The court’s ‘justice’ fails to grasp this concept though, so the lies win the struggle once again. Act 3 holds the best chance Salem has had of being released from the hysteria and madness that has accumulated and multiplied, feeding upon the accusations and lies that have been propagated, but this glimmer of hope is extinguished, and the truth is once again suppressed and shunned. The truth of the girls’ fraud is suppressed. From the very beginning, when Proctor first speaks out against the court, Danforth’s questioning techniques attempt to intimidate Proctor, thus trying to suppress the truth, because his dialogue is imposing, inflexible and intimidating, thus preventing the one person who holds the key to the release of Salem, the one person who knows and can tell the truth, from doing so. ‘If I must answer that, I will leave and not come back again. ‘ The other character key to suppressing the truth is Abigail, because she is harnessing the power of the witch trials to eliminate Elizabeth, to clear the path to her lust for Proctor, she also has an intimidating dialogue, because hers is indignant, and at times, even threatening, cleverly making out that she is innocent. She acts the part of a girl who is shocked and indignant at the charge against her, making the charge seem entirely false, when in reality it is completely accurate. She pretends to be indignant at the questions, to avoid answering the questions that Danforth poses to her, and even threatens to leave the court, showing her growing power over the adults in Salem. She also keeps looking at Mary, and uses the apparitions of the yellow bird and the icy wind, to force Mary back to her side, once again suppressing the truth from one character that could be the end of the lies. She chatters her teeth and shakes, to make the apparitions seem even more realistic. There are also events in Act 3 that also show the suppression of the truth, such as Danforth and Hathorne questioning Proctor to try to suppress the truth. In order to try to dispose of the threat that Proctor begins to pose in Act 3, Danforth and Hathorne exercise their power to invade his privacy. Even though Proctor has not yet been formally accused of witchcraft, Danforth and Hathorne, like Hale earlier, question him about his Christian morals as though he were already on trial. They hope to find in his character even the slightest deviation from Christian doctrine because they would then be able to cast him as an enemy of religion. Once thus labelled, Proctor would have virtually no chance of anyone in God-fearing Salem intervening on his behalf, therefore suppressing the truth. The court created for the witch trials was commonly believed by the villagers to be created by God. Therefore the upholding of this court becomes essential to the maintenance of social order in Salem. There is a big decision to be made by the judges in this act- to maintain social order and suppress individuals’ freedom, or to submit to the truth, thus condemning Salem to chaos and their reputation to breakdown. Some dramatic devices in this act are used to emphasise the issue of the decision between maintenance of social order or the truth. When Judge Danforth enters, the rest of the characters including Cheever and Parris trail him. This positioning of characters emphasises the authority that Danforth possesses. On his appearance, silence falls, again showing his power and authority as high judge of the court. He has the power to suppress the truth or to give justice, to take away the lives of innocents, or to heal Salem of the wounds it has suffered. ‘Let you consider it then. ‘ When Hale says this sentence, the room falls silent as Proctor hands Danforth the warrant. This is a dramatic climax, when Danforth is considering Proctor’s evidence. This is a fulcrum, where the verdict could go either way-where social order could be maintained, or Proctor’s individual freedom could be granted. The silence is broken only by Mary’s sob, showing the importance of this moment. ‘I have evidence for the court!†¦ we have proof for your eyes’ The desperate attempt by Giles, Proctor and Francis to save their respective wives exposes the extent to which the trials have become about specific individuals and institutions struggling to maintain power and authority-social order versus individual freedom. Danforth and Hathorne do not want to admit publicly that they were deceived by a group of girls, while Parris does not want the trials to end as a fraud because the scandal of having a lying daughter and niece would end his career in Salem. Because of this, Danforth react to Proctor’s claims by accusing him of trying to undermine the court, which, in theocratic Salem, is tantamount to undermining God himself. The issue that you’re one’s name is important to one, and that some are willing to die for it. There are many contextual links and quotes, from plays, books and even the bible, stating that name is important to a man. ‘Good name in man and women, dear my lord, is the immediate jewel of their souls; who steals my purse steals trash; ’tis his, and has been slave to thousands; but he that filches from me my good name robs me of that which not enriches him, and makes me poor indeed’ This quote form the play ‘Othello’ by Shakespeare shows that a name is important to a man, more important than his money or possessions. ‘I quit this court! ‘ The stage direction of Hale slamming the door after quitting the court from which he was part of, ruins his good name and relinquishes the power he held, because he realises the injustice and lies that are holding the court up. ‘Their bodies are buried in peace, but their name shall liveth for evermore. ‘ This quote from the bible, of St Matthew, Chapter 44, verse 9 says that if someone is dead, but has not left a name behind them, it means that they have not sinned and their name shall live on forever. Giles acted upon the same principle in this act-‘I cannot give you his name. ‘ Giles refuses to name someone else just so he can keep his own life, and dies for the cause. Proctor in this act also does not defile his name, because he does not confess to witchcraft when prompted, so is thrown in jail with a death sentence. He instead speaks the truth-that Salem has ‘pulled down heaven and raised up a whore. ‘ In conclusion, in Act 3 of the crucible, Miller uses dramatic devices and events to highlight the key issues of the play, and, indeed, of the time, highlighting the problems and issues with Puritanism and the way of life in those days, and highlights the paranoia and hysteria that flourished in Salem at the time. He realises the irony of the trials, that they were supposed to be God’s will, but people were in fact using religion to their own ends. By Luke Worley (9T) 2915 words. Show preview only The above preview is unformatted text This student written piece of work is one of many that can be found in our GCSE Arthur Miller section.

Brand Image of a University

INTRODUCTION Origin of Report As a part of our Marketing 465, Brand Management course, we learnt the various aspects of marketing and the management of brands. Problem and Purpose We were assigned a project where we were asked to find out the brand image of private university business graduates; and more specifically, the brand image of North South University, its positioning and state any improvements if necessary. Scope and Limitations The main limitation of this project was the lack of time required to carry out the type of research this project requires. Historical Background †¦ Hypothesis We hoped to establish that North South University is the best private university in Bangladesh. Research Methodology As stated previously, due to the lack of time we were not able to conduct the type of in-depth research that this project required. Instead the basis of our research were a set of in-depth interviews we carried out among various categories of people, such as current students of North South University, alumni, guardians, faculties, prospective/current employers, students of other universities, faculties of other universities, the University Grants Commission, prospective students, and the general public. There were sets of questions (See Appendix) for the various categories, and interviews were taken accordingly. THE SURVEY Findings Current Student For the current students who study at North South University, this is the best alternative for us after IBA and going abroad for studies. It’s the pioneer private university in Bangladesh, and quite popular. Even though through the years the quality of NSU has diminished, there are too many students taken in, and especially through the â€Å"backdoor† policy, and it’s become really unfair to those who work hard. However, NSU still has a lot of good name, and people do have goodwill towards it. Alumni According to the questions asked to Alumni of North South University, they believe that NSU’s graduates have an advantage over other graduates of other schools because they are more fluent in English, smart, and easily adaptable with the organizational environment. Guardians According to guardians of students studying in North South University, they believe that NSU graduates will be able to have: Jobs in MNC, monetary benefit, and be able to finish graduation quickly. They also believe that NSU is highly competitive, has the best educational quality, and the best faculty. Faculties According to faculties believe that NSU is a good university but not as good as IBA. This is because IBA concentrates more on practical fieldwork, where NSU is still lacking. Another factor they said that NSU has very short semesters, so faculties aren’t able to cover their topics completely. However, NSU students have good presentation skills, are intelligent and also street smart. Employers Certain employers believe that the graduates that come out of NSU are very hot-headed and pompous, and many of them have high CGPAs but cannot even communicate properly in the English language. NSU is believed to be the next best alternative to IBA. IBA might have worse teachers, but their student intake is much better. Students of other universities Students of other universities believe that a private university’s business program provides better job opportunities. Private universities are more efficient than pubic universities. North South University is very popular and quite sought after. University staff The university staff believes that the environment of NSU is not good. They brought up issues regarding clothing and student’s behaviour. They think students are very rude and disrespectful. University Grants Commission There are several factors through which the UGC grants a university, it focuses on infrastructure, faculties, how much money there is in the fund to make their own campus etc. Then in order to rank a university, they see how many students compete for a single seat during the admission process, the value of the certificate in the job sector, the quality of the faculties and the quality of the students. A complaint they made is that all universities are expected to shift to their new campus within 5 years of establishment, but none of the private universities have been able to do so. Prospective Students Most of the prospective students we interviewed, around the age of 16-18, none of them want to come to NSU. They believe that NSU is becoming too overrated and crowded. They would either try for abroad, or a public university, and then try for a private university. General Public In the eyes of the general public, NSU is still very sought after and considered a very good place for education. It’s only the people who are direct recipients of NSU’s output, the students and the employers who are affected the most. NSU students are seen are very culturally â€Å"fast† and ignorant. Conclusion After research we can conclude that academically, the students of NSU are good but there are behavioral and attitude problems among themselves. They’re more ignorant about what’s going on outside of NSU and they’re very pompous and they lack professionalism in the corporate world. There are a certain percentage of students who create a bad image for NSU, so most students are slammed with this label as well. But NSU comprises of all types of students from various social and economical backgrounds and not all are bad. Recommendations Alumni: Teaching method should be more practical based Internship in a good organization is very important. CPDS of NSU should be efficient enough to manage their graduates’ internship in a good organization NSU should organize more and more seminar, workshop regarding different organizational issues. University staff correct English grammar in both reading and writing environmental discipline cultural discipline manner build up moral character dress code study more Employers NSU should increase their employability NSU’s image is of No. 2, they should raise it to No. 1 NSU should move on to the researching level and provide consultancy to the different companies. Most foreign universities do consultancy work for companies on their countries. It really sets the standard for good quality education. Universities should talk to employers and brush up on the curriculum NSU should go for downward extension and start from the grassroots level. They should create primary and secondary level education so that the students go directly to the university level.

Heroes in Chivalry Essay Example

Heroes in Chivalry Essay Example Heroes in Chivalry Paper Heroes in Chivalry Paper Roland and Lancelot: Heroes in Chivalry Since the dawn of time heroes have come and gone, some won battles and others lost wars but all have been remembered through the generations as lessons, for better or worse, of morality and timeless human themes. No period In history is more synonymous with hero worship as the Medieval ages. Throughout these times some of the most famous tales of knights, kings, and chivalry were penned, none more so than the stones of Roland, a great warrior under King Charlemagne, and Sir Lancelot, a knight of King Urethras. Willing to suffer for their respective causes, their honor and the honor of their allies were of utmost Importance to them. These two men both personified and exemplified the classic facets of medieval song and romance, chivalry and courtly love, In many ways, but they do so In significantly assistance when confronted with an overwhelming opposing army for fear of the besmirching of his and his countrys honor. In Christie De Tropes Lancelot, Gain and Lancelot set out in quest of Queen Guinevere. Both value honor above all else and are willing to fight for it. When given the suggestion that he should call for aid in battle, Roland replies, Almighty God forbid that I bring shame upon my family,and causes sweet France to fall into disgrace! Ill strike that horde with my good [sword). When Lancelot, during his dual with his loves captor, sees Guinevere watching him his devotion to her and his hatred of his opponent make him so fiery that Inelegant [surrenders]. Their adherence to the code of chivalry and the gravity of honor felt by these two men caused both to do things others would not and thus Amortized them as heroes. Though both are protecting honor of one kind or another, Lancelot and Roland have two very different reasons for doing so. Roland is refusing reinforcements so as to not seem a coward, while Lancelot is seeking a woman. While both are displaying the highest amount of chivalry, only Lancelot can be said to be trying to woo and win his ladys heart. This noble application of so called courtly love is what sets Lancets aims of attaining love and romance apart from Reloads; to retain the glory of France and gain fame for his king, his men, and himself. Another aspect of chivalry portrayed In both accounts Is the dependence placed by both champions on combat, fighting, and the usage of cavalry. Both combatants in the tale of Lancelot are Incredibly adept horsemen and swordsmen, so much Is their skill and power of fighting, that their collision seems Like a mighty thunder-clap and both sustained [catheters blows] with equal honor. While Roland enters battle riding his charger, swift-running Flagellant and so potent of a warrior Is he that his enemies, the pagans flee Trying their best to get away. The lowercasing of blood-and-thunder heroism In these readings and the presentation of the two aforementioned characters as plantations of physical courage and personal loyalty in both cases further cements them as to of the greatest, mos t chivalrous heroes of all time. Not only is their fighting a demonstration of their chivalry and courtly love but the lengths to which they are willing to go is even more exemplary. Roland was willing to die for his religious devotion and for his king; he never lost slant AT want was Important to Nils own Dealer system, even as en met Nils ND, laying on the ground, he placed beneath himself his sword and his horn, his head facing pagan Spain, so King Charlemagne and all the Franks would say that he, Count Roland conquered until he died. Just as Roland was willing to die, so too was Lancelot in his quest for Guinevere, though he did not have to, he needed only to endure excruciating pain. Sacrifice is a major characteristic of chivalry and courtly love; it is said that to love is to suffer, and there is no doubt that either man loved his respective creed. The Song of Roland and Christie De Tropes Lancelot are two of he most majestic chronicles of honor and morality in all of history. Their timeless lessons in chivalry are applicable even today, many hundreds of years after their conception. The significance of upholding honor, physical and mental fortitude, and willingness to sacrifice and attempt the unimaginable for an important cause is easily discerned from both antecedent heroes accounts. The chivalry shown by Sir Lancelot and Count Roland is inexorably similar yet still maintains an arms length difference of originality that sets them apart as two classic renditions of medieval noble ideals.

Biography of Sonni Ali, Songhai Monarch

Biography of Sonni Ali, Songhai Monarch Sonni Ali (birth date unknown; died 1492) was a  West African monarch who ruled Songhai from 1464 to 1492, expanding a small kingdom along the Niger River into one of medieval Africas greatest empires. Two divergent historical accounts of his life persist: the Muslim scholarly tradition that paints him as an infidel and tyrant and the oral Songhai tradition that remembers him as a great warrior and magician. Fast Facts: Sonni Ali Known For:  West African monarch of Songhai; expanded his empire, superseding the Mali empireAlso Known As:  Sunni Ali and Sonni Ali Ber (The Great)Born:  UnknownParents: Madogo (father); mothers name unknownDied:  1492Education: Traditional African arts education among the Faru of SokotoChildren: Sunni Baru Two Divergent Versions of Sonni Alis Life There are two main sources of information about Sonni Ali. One is in the Islamic chronicles of the period and the other is through Songhai oral tradition. These sources reflect two very different interpretations of Sonni Alis role in the development of the Songhai Empire. Early Life Little is known about Sonni Alis early life. He was schooled in the traditional African arts of the region and was well versed in the forms and techniques of warfare when he came to power in 1464 in the small kingdom of Songhai, which was centered around its capital city of Gao on the Niger River. He was the 15th consecutive ruler of the Sonni dynasty, which had begun in 1335. One of Alis ancestors, Sonni Sulaiman Mar, is said to have wrested Songhai away from the Mali Empire toward the end of the 14th century. Songhai Empire Takes Over Although Songhai had once paid tribute to the rulers of Mali, the Mali Empire was now crumbling and the time was right for Sonni Ali to lead his kingdom through a series of conquests at the old empires expense. By 1468, Sonni Ali had repulsed attacks by the Mossi to the south  and defeated the Dogon in the hills of Bandiagara. His first major conquest occurred in the following year when the Muslim leaders of Timbuktu, one of the great cities of the Mali Empire, asked for help against the Tuareg, the nomadic desert Berbers who had occupied the city since 1433. Sonni Ali took the opportunity not only to strike decisively against the Tuareg  but also against the city itself. Timbuktu became part of the fledgling Songhai Empire in 1469. Oral Tradition Sonni Ali is remembered in Songhai oral tradition as a magician of great power. Rather than following the Mali Empire system of Islamic city rule over a non-Islamic rural people, Sonni Ali mixed an unorthodox observance of Islam with traditional African religion. He remained attached to the traditional rites of his mothers birthplace, Sokoto. He was a man of the people rather than the elite ruling class of Muslim clerics and scholars. According to the oral tradition, he is regarded as a great military commander who carried out a strategic campaign of conquest along the Niger River. He is said to have retaliated against the Muslim leadership within Timbuktu after they failed to provide promised transport for his troops to cross the river. Islamic Chronicles The Islamic chroniclers have a different viewpoint. They portray Sonni Ali as a capricious and cruel leader. In the 16th century chronicle of Abd ar Rahmen as-Sadi, a historian based in Timbuktu, Sonni Ali is described as an impious and unscrupulous tyrant. Sonni Ali is recorded as having massacred hundreds while plundering the city of Timbuktu. This routing included killing or driving out the Tuareg and Sanhaja clerics who had acted as civil servants, teachers, and as preachers at the Sankore mosque. In later years, according to this historian, he is said to have turned on court favorites, ordering executions during temper tantrums. More Conquest Regardless of the precise interpretation of history, it is certain that Sonni Ali learned his military lessons well. Never again was he left at the mercy of someone elses fleet. He built up a river-based navy of more than 400 boats and used them to good effect in his next conquest, the trading city of Jenne (now Djennà ©). The city was placed under siege, with the fleet blockading the port. Although it took seven years for the siege to work, the city fell to Sonni Ali in 1473. The Songhai Empire now incorporated three of the greatest trading cities on the Niger: Gao, Timbuktu, and Jenne. All three had once been part of the Mali Empire. Trade Rivers formed the major trading routes within West Africa at that time.  The Songhai Empire now had effective control over the lucrative Niger River trade of gold, kola, grain, and slaves.  The cities were also part of the important trans-Saharan trade route system which brought south caravans of salt and copper, as well as goods from the Mediterranean coast. By 1476, Sonni Ali controlled the inland delta region of the Niger to the west of Timbuktu and the lakes region to the south. Regular patrols by his navy kept the trade routes open and tribute-paying kingdoms peaceful. This is an extremely fertile region of West Africa, and it became a major producer of grain under his rule. Slavery A 17th-century chronicle tells the tale of Sonni Alis slave-based farms. When he died, 12 tribes of slaves were bequeathed to his son, at least three of which had been obtained when Sonni Ali initially conquered parts of the old Mali empire. Under the Mali Empire, slaves were individually required to cultivate a measure of land and provide grain for the king. Sonni Ali changed this system and grouped the slaves into villages, each required to fulfill a common quota, with any surplus to be used by the village. Under Sonni Alis rule children born in such villages automatically became slaves. They were expected to work for the village or to be transported to the trans-Saharan markets. Sonni Ali the Warrior and Ruler Sonni Ali was brought up as part of an exclusive ruling class, a warrior horseman. The region was the best for breeding horses in Africa south of the Sahara. As such he commanded an elite cavalry, with which he was able to pacify the nomadic Tuareg to the north. With cavalry and  navy, he repulsed several attacks by the Mossi to the south, including one major attack which reached all the way to the Walata region northwest of Timbuktu. He also defeated the Fulani of the Dendi region, which was then assimilated into the Empire. Under Sonni Ali, the Songhai Empire was divided up into territories, which he placed under the rule of trusted lieutenants from his army. Traditional African cults and the observance of Islam were combined, much to the annoyance of Muslim clerics in the cities. Plots were hatched against his rule. On at least one occasion, a group of clerics and scholars at an important Muslim center were executed for treason. Death Sonni Ali died in 1492 as he returned from a punitive expedition against the Fulani.  Oral tradition claims he was poisoned by Muhammad Ture, one of his commanders. Legacy A year after Alis death, Muhammad Ture staged a coup detat against Sonni Alis son Sonni Baru and founded a new dynasty of Songhai rulers. Askiya Muhammad Ture and his descendants were strict Muslims, who reinstated orthodox observance of Islam and outlawed traditional African religions. As with his life, his legacy has two very different interpretations in the oral and Muslim traditions. In the centuries which followed his death, Muslim historians recorded Sonni Ali as The Celebrated Infidel or The Great Oppressor. Songhai oral tradition records that he was the righteous ruler of a mighty empire that encompassed more than 2,000 miles (3,200 kilometers) along the Niger River. Sources Dobler, Lavinia G, and William Allen Brown. Great Rulers of the African Past. Doubleday, 1965 Gomez, Michael A.,  African Dominion: A New History of Empire in Early and Medieval West Africa. Princeton University Press, 2018Tesfu, Julianna. â€Å"Songhai Empire (Ca. 1375-1591) BlackPast.†Ã‚  BlackPast.â€Å"The Story of Africa| BBC World Service.†Ã‚  BBC News, BBC.

Biochemistry Assessment Assignment Example | Topics and Well Written Essays - 2500 words

Biochemistry Assessment - Assignment Example his increase in boiling point is due to higher number of carbons in butyric acid as compared to acetic acid; number of carbons is one of the criteria on which boiling point depends. Aldehydes and ketones both contain carbonyl group (C=O). When C=O is at the end of carbon chain, and carbon has two single bonds, one with other carbon and one with a hydrogen, then it’s an aldehyde. Vanillin is a phenolic aldehyde which is added to beverages and foods as a flavoring agent. It’s also found in French fries (trans fats). 9.Sucrose and honey are commonly used sweeteners.   Suppose you had a sweet-tasting water solution that contained either honey or sucrose.   How would you chemically determine which sweetener was present? For sucrose, resorchinol (1, 3-benzenediol) can be used to detect for the presence of sucrose in the solution. Resorchinol indicator solution is prepared by adding 0.05 g of reagent-grade resorchinol in 100 ml of HCl solution. 1 ml of freshly prepared indicator solution is mixed with 5 drops of 1 % unknown solution and heated to boiling point. If it turns to cherry red color after a few minutes, it indicates presence of sucrose, if it turns to other colors like yellow or salmon then sucrose is not present. Denaturation of proteins results in disruption and destruction of secondary and tertiary structures. As the process is not that much strong to break peptide bonds, so primary structure (sequence of amino acids) remains intact. However, alpha-helix and beta sheets are disrupted resulting in random shapes. 1. Messenger RNA (mRNA) is responsible for carrying the genetic information which is copied from DNA. This information is copied as a series of three-base code â€Å"words,† which are specific for a particular amino acid. 2. Transfer RNA (tRNA) has an important role of understanding and interpreting the genetic code carried by mRNA. In this regard, each amino acid has a specific type of tRNA. This